varSEAK A VARIANT DATABASE
SUPPORTING YOUR RESULT INTERPRETATION &
CONNECTING YOU WITH GENETICIANS WORLDWIDE

NO CLOUD - STAY IN CONTROL OF YOUR DATA

varSEAKvarShared Experience And Knowledge

Worldwide more than 500 SEQUENCE Pilot (CE-IVD certified) installations are used to analyse Sanger and Next Generation Sequencing data. Over the last decade genetic laboratories maintained their local databases containing up to 20 % of variants that are not listed in any publicly available database and acquired a lot of knowledge and experience.

The varSEAK family with its editions varSEAK Pilot, varSEAK Open, varSEAK Consortium and varSEAK Online is a bundle of new software tools, automatically aggregating all these valuable information in one central database in real time and offering convenient access to the varSEAK community.
 

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varSEAK Pilot is the professional all-in-one solution to comfortably manage and interpret sequencing data. Directly connected to SEQUENCE Pilot for a seamless and time-saving integration into your daily workflow.

varSEAK Open is intended for every genetic facility that does not use SEQUENCE Pilot (yet). The same functionality as in varSEAK Pilot is offered, based on the import of vcf-files from any sequencing analysis software.

varSEAK Consortium allows for close collaboration of several genetic facilities. Do not hesitate to contact us for your tailor-made solution!

varSEAK Online offers free access to the varSEAK database and our Splice Site Prediction Tool.

  • HIGHLIGHTS

    • Fast and reliable solution to manage, filter, interpret and classify genetic variants, based on a lab internal installation (varSEAK Pilot or varSEAK Open) which is connected to a global database and communication instance (varSEAK global server)
    • Easy import of the internal SEQUENCE Pilot mutation database into varSEAK Pilot
    • Automatic or manual transfer of order details including the distinct variants from SEQUENCE Pilot into varSEAK Pilot
    • Easy import of VCF files with data from other sequencing pipelines into varSEAK Pilot or varSEAK Open
    • Detailed lab internal classification of variants in varSEAK Pilot or varSEAK Open (including HPO-compliant phenotypes, mode of inheritance, documents, weblinks, PubMed-IDs, medical reports…)
    • Connected to the varSEAK global database server to access bundled information:
      • Public databases (e.g. dbSNP, 1000 Genomes, ClinVar, ESP, ExAC, gnomAD, p53, UK10K, Mutation-Taster and SIFT)
      • ACMG compliant classifications from other varSEAK users

     

    • Highly flexible and adaptable functions to filter the detected variants (phenotype, genomic regions, genes/gene panels, splice site prediction, classifications, AF/MAF, etc.) with current data from the varSEAK global database
    • Automatic Splice Site Prediction for every imported variant with over 96% accuracy
    • Synchronisation of filter results, validation state and classifications between SEQUENCE Pilot and varSEAK Pilot
    • Generation of individual variant reports for each patient
    • Internal communication tool to contact other users or labs that identified the same variant or variants in close genomic proximity
    • Optional submission of classified variants to the varSEAK global database (submitted data: the identified variant, the ACMG classification tier (1-5), the name of the lab)

     

  • PRODUCT BROCHURE

    Download our product brochure and
    find out more about our products!

    JSI Product Brochure 2022


  • Fast and reliable solution to manage, filter, interpret and classify genetic variants, based on a lab internal installation (varSEAK Pilot or varSEAK Open) which is connected to a global database and communication instance (varSEAK global server)
  • Easy import of the internal SEQUENCE Pilot mutation database into varSEAK Pilot
  • Automatic or manual transfer of order details including the distinct variants from SEQUENCE Pilot into varSEAK Pilot
  • Easy import of VCF files with data from other sequencing pipelines into varSEAK Pilot or varSEAK Open
  • Detailed lab internal classification of variants in varSEAK Pilot or varSEAK Open (including HPO-compliant phenotypes, mode of inheritance, documents, weblinks, PubMed-IDs, medical reports…)
  • Connected to the varSEAK global database server to access bundled information:
    • Public databases (e.g. dbSNP, 1000 Genomes, ClinVar, ESP, ExAC, gnomAD, p53, UK10K, Mutation-Taster and SIFT)
    • ACMG compliant classifications from other varSEAK users
  • Highly flexible and adaptable functions to filter the detected variants (phenotype, genomic regions, genes/gene panels, splice site prediction, classifications, AF/MAF, etc.) with current data from the varSEAK global database
  • Automatic Splice Site Prediction for every imported variant with over 96% accuracy
  • Synchronisation of filter results, validation state and classifications between SEQUENCE Pilot and varSEAK Pilot
  • Generation of individual variant reports for each patient
  • Internal communication tool to contact other users or labs that identified the same variant or variants in close genomic proximity
  • Optional submission of classified variants to the varSEAK global database (submitted data: the identified variant, the ACMG classification tier (1-5), the name of the lab)

Download our product brochure and
find out more about our products!

JSI Product Brochure 2022