I have been on www.varSEAK.bio and it is just a database. What is the difference between www.varSEAK.bio („varSEAK Online“) and varSEAK Pilot?
The www.varSEAK.bio website offers free and public access to the varSEAK database. The varSEAK variant database comprises numerous public databases including direct links, eliminating the need for laborious searches. On top of that, varSEAK offers ACMG conform classifications submitted by genetic professionals using the varSEAK Pilot or varSEAK Open software module.
The varSEAK Pilot software module can be seamlessly integrated into your SEQUENCE Pilot workflow. It serves to conveniently filter your orders, characterise and classify variants, including ACMG-criteria, HPO-conform phenotypes, descriptions, inheritance patterns, attached documents and weblinks. Moreover, varSEAK is designed as a communications network, simplifying making contact with other genetic experts for professional exchange.
Please refer to our Products page for more details.
Is varSEAK cloud-based?
varSEAK is not cloud-based. All patient data stays safe within the varSEAK Pilot or varSEAK Open installation inside the local network. All public database and varSEAK database information are stored on the varSEAK global server and can be queried from varSEAK Online, varSEAK Pilot or varSEAK Open. Therefore, it is necessary that the local varSEAK Pilot or varSEAK Open installation has permanent internet access to the varSEAK global server. For more details, please refer to Hardware Requirements for varSEAK.
How does the ‚varSEAK Classification‘ come about?
The varSEAK Classification is the average of the submitted classifications from the institutions using varSEAK Pilot or varSEAK Open. The value is given both as a word and in digits.
What do the numbers in the line below the varSEAK Classification mean?
The numbers serve to elucidate the occurrence of the varSEAK Classification: it shows how often each class has been submitted. Each position stands for one class, from class 1 (benign) on the left to class 5 (pathogenic) on the right. The numbers account for the varSEAK users having submitted the respective classification.
Example: (0/0/0/1/2) would mean that the variant has been classified as „likely pathogenic“ (class 4) by one varSEAK user and as „pathogenic“ (class 5) by two varSEAK users.
What data is submitted to the varSEAK database?
To request database information to be displayed in varSEAK Pilot, only the variant (chromosome, position, reference sequence, altered sequence) is used.
When submitting a variant, the sent data are: the variant (including transcript/HGVS nomenclature), its classification (ACMG classification tier only, no additional information) and the laboratory (as submitter). No patient or order related data is ever transferred to the global varSEAK database.
What does varSEAK cost?
varSEAK Online is publicly accessible and free of charge.
The locally installable varSEAK software (varSEAK Pilot, varSEAK Open, varSEAK Consortium) is available in several configurations. For a quote or price list, please contact our varSEAK support team.
I would like to try varSEAK. What do I need to do?
I would like a combined trial license of SEQUENCE Pilot and varSEAK Pilot:
Please use our contact form to request your free trial license.
I am already using SEQUENCE Pilot:
Please contact our varSEAK support team and let us know you are interested in a trial license. Please state your and your institution‘s/department‘s contact details so we can assign your request correctly.
I have another question…
Please contact our varSEAK support team - we are happy to help.